ד"ר רם שרוני

מנהל היחידה לניתוחי לב זעיר פולשניים, בילינסון

יליד הארץ. לאחר שירות צבאי (5 שנים, לוחם בסיירת גולני ובהמשך מ"פ בגולני) למד בבית הספר לרפואה באונ' בן גוריון (מצטיין מדעי הרפואה), התמחות במחלקה לניתוחי לב בבית חולים כרמל, חיפה. בהמשך יצא לתת התמחות (Fellowship) במשך שנתיים ב- NYU, ארה"ב, במרכז המוביל בניתוחי לב זעיר פולשניים. במקביל, חקר במעבדה תגובות דלקתיות לארטריאליזציה של ורידים וכן מחקר קליני. עם שובו ארצה היה רופא בכיר במרכז רפואי תל אביב ומשנת 2008 ועד עתה רופא בכיר במחלקת ניתוחי לב במרכז רפואי רבין (בילינסון) שם הוא מנהל את היחידה לניתוחי לב זעיר פולשניים.

ד"ר שרוני משמש כמרצה בכיר באוניברסיטת תל אביב ואחראי על הוראה הסטודנטים במחלקה.
בנוסף, ד"ר שרוני מדריך ניתוחים במרכזים רפואיים בחו"ל בתחום ניתוחי לב זעיר פולשניים ובהשתלת מסתם ללא תפרים.

במהלך ״חרבות ברזל״ ד״ר שרוני טיפל בחייל מיחידה  מובחרת אשר נפצע בידו ורסיס התגלה בליבו
הטיפול העמיד דילמות אשר פורסמו בעיתונות המקצועית הבינלאומית

1. Sharony R., M. Saute, G. Uretzky.
Video assisted thoracic surgery: our experience with 102 patients.
J Cardiovasc Surg., 35 (Suppl, 1 to No 6):173-6; 1994.

2. Saute M., Sharony R., Uretzky G.
Muscle sparing thoracotomy, a new approach in chest surgery.
Harefuah 129(12):8-9, July 1995.

3. Sharony R., Olivson A, Berman E, Uretzky G, Schwalb H.
A 31P NMR study of preconditioned isolated perfused rat heart exposed to intermittent ischemia.
Mag. Reson. Med., 1996 Jul;36(1):66-71.

4. Amiel GE, Cohen R, Amar R, Sarafov I, Safadi T, Saute M, Porat E, Sharony R, Bolotin G, Tann M, Uretzky G.
Using a video-conference to teach clinical students in a one week cardiothoracic surgery clerkship.
Am J Surg. 1997 Apr;173(4):330-2.

5. Saute M, Sharony R., Bolotin G, Sarafov I, Porat E, Uretzky G.
Videothoracoscopic sympathectomy – a single port, drainless procedure for the treatment of palmar hyperhidrosis.
S Am J Thorac Surg 1997; 1:22-24.

6. Borman JB, Deviri E, Bitran D, Silberman S, Locker C, Yakirevich V, Sharony R, Uretzky G.
The Sorin Bicarbon valve: clinical evaluation in Israel.
J Cardiovasc Surg (Torino) 1998 Feb;39(1):99-102.

7. Borman JB, Brands WG, Camilleri L, Cotrufo M, Daenen W, Gandjbakhch I, Infantes C, Khayat A, Laborde F, Pellegrini A, Piwnica A, Reichart B, Sharony R, Walesby R, Warembourg H.
Bicarbon valve – European multicenter clinical evaluation.
Eur J Cardiothorac Surg 1998 Jun;13(6):685-93.

8. Sharony R, Porat E, Nishimura Y, Meyns B, Ozaki S, Racz R, Flameng W, Uretzky G.
The intra-aortic cannula pump (IACP): a novel assist device for the acutely failing heart.
J Thorac Cardiovasc Surg, 1999, Nov; 118(5): 924-9.

9. Porat E, Sharony R, Ivri S, Ozaki S, Meyns B, Flameng W, Uretzky G.
Hemodynamic changes and right heart support during vertical displacement of the beating heart.
Ann Thorac Surg, 69(4):1188-91, 1999.

10. Kitzes-Cohen R, Farin D, Piva G, Ivry S, Sharony R, Amar R, Uretzky G.
Pharmacokinetics of Vancomycin administered as prophylaxis before cardiac surgery.
Ther Drug Monit, Vol 22, No 6, 661-7, 2000.

11. Galili R, Nesher N, Sharony R, Uretzky G, Saute M.
Video-assisted thoracic surgery–experience with 586 patients.
Harefuah. 2001 Feb;140(2):91-4, 192.

12. Nesher N, Galili R, Sharony R, Uretzky G, Saute M.
Videothorascopic sympathectomy (VATS) for palmar hyperhidriosis: Summary of a clinical trial and surgical results.
Harefuah. 2000 Jun 1;138(11):913-6, 1008.

13. Nesher N, Wolf T, Kushnir I,David M, Bolotin G, Sharony R, Pizov R, Uretzky G.
Novel thermoregulation system for enhancing cardiac function and hemodynamics during coronary artery bypass graft surgery.
Ann Thorac Surg. 2001 Sep;72(3):S1069-76.

14. Nesher N, Insler SR, Sheinberg N, Bolotin G, Kramer A, Sharony R, Paz Y, Pevni D, Loberman D, Uretzky G.
A new thermoregulation system for maintaining perioperative normothermia and attenuating myocardial injury in off-pump coronary artery bypass surgery.
Heart Surg Forum 2002;5(4):373-80.

15. Sharony R., E. Porat , R. Autschbach, M. Struber, A. Boening, R. Kracor, A. Haverich, J. Cremer, N. Nesher and G. Uretzky.
Right heart support during off pump coronary artery bypass surgery – a multi center study. Heart Surg Forum, Vol 5(1), 2002.

16. Nesher N, Zisman E, Wolf T, Sharony R, Bolotin G, David M, Uretzky G, Pizov R.
Strict thermoregulation attenuates myocardial injury during coronary artery bypass graft surgery as reflected by reduced levels of cardiac-specific troponin I.
Anesth Analg. 2003 Feb;96(2):328-35.

17. Grossi EA, Bizekis CS, Sharony R, Saunders PC, Galloway AC, Lapietra A, Applebaum RM, Esposito RA, Ribakove GH, Culliford AT, Kanchuger M, Kronzon I, Colvin SB.
Routine intraoperative transesophageal echocardiography identifies patients with atheromatous aortas: impact on "off-pump" coronary artery bypass and perioperative stroke.
J Am Soc Echocardiogr. 2003 Jul;16(7):751-5

18. Sharony R, Grossi EA, Saunders PC, Schwartz CF, Ciuffo GB, Baumann FG, Delianides J, Applebaum RM, Ribakove GH, Culliford AT, Galloway AC, Colvin SB.
Aortic valve replacement in patients with impaired ventricular function.
Ann Thorac Surg. 2003 Jun;75(6):1808-14.

19. Sharony R, Grossi EA, Bizekis CS, Ribakove GH, Galloway AC, Schwatz FC, Culliford AT, Ursomanno P, Sennet DM, Baumann GF, Colvin SB.
Minimally Invasive Aotic Valve Surgery in the Elderly: A Case-Control Study. Circulation. 2003 Sep 9;108 Suppl 1:II43-7.

20. Sharony R, Bizekis CS, Grossi EA, Galloway AC, Applebaum RM, Schwatz FC, Ribakove GH, Culiford AT, Kanchuger M, Kronzon I, Colvin SB.
Off Pump CABG Reduces Mortality and Neurologic Complications in Patients with Atheromatous Aortas: A Case Control Study.
Circulation, 2003 Sep 9;108 Suppl 1:II15-20.

21. Bizekis CS, Pintucci G, Derivaux CC, Saunders PC, Saponara F, Kim JH, Hyman KM, Sharony R, Grossi EA, Baumann FG, Mignatti P, Galloway AC.
Activation of mitogen-activated protein kinases during preparation of vein grafts and modulation by a synthetic inhibitor.
J Thorac Cardiovasc Surg. 2003 Sep;126(3):659-65. Erratum in: J Thorac Cardiovasc Surg. 2003 Nov;126(5):1680.

22. Pintucci G, Yu PJ, Sharony R, Baumann FG, Saponara F, Frasca A, Galloway AC, Moscatelli D, and Mignatti P.
Induction of stromelysin-1 (MMP-3) by fibroblast growth factor-2 (FGF-2) in FGF-2-/- microvascular endothelial cells requires prolonged activation of extracellular signal-regulated kinases-1 and -2 (ERK-1/2).
J Cell Biochem. 2003 Dec 1;90(5):1015-25

23. Sharony R, PC Saunders, A Nayar, E McAleer, A C Galloway, J Delianides, CF Schwartz, RM Applebaum, I Kronzon, SB Colvin and EA Grossi.
Semi-Rigid Partial Annuloplasty Band Allows Dynamic Mitral Annular Motion and Minimizes Valvular Gradients: An Echocardiographic Study.
Ann Thorac Surg. 2004 Feb;77(2):518-22

24. Sharony R, EA Grossi., PC Saunders, AC Galloway, RM Applebaum, GH Ribakove, AT Culliford, M Kanchuger, I Kronzon, and SB Colvin.
Propensity Case Match Analysis of Off Pump CABG in Patients with Atheromatous Aortic Disease.
J Thorac Cardiovasc Surg. 2004 Feb;127(2):406-13.

25. PC Saunders, EA Grossi, R Sharony, CF Schwartz, GH Ribakove, AT Culliford., J Delianides, FG Baumann, AC Galloway, SB Colvin.
Minimally Invasive Technology for Mitral Valve Surgery via Left Thoracotomy: Experience with Forty Cases.
J Thorac Cardiovasc Surg. 2004 Apr;127(4):1026-32.

26. Dayan JH, Oliker A, Sharony R, Baumann FG, Galloway A, Colvin SB, Miller DC, Grossi EA.
Computer-Generated Three-Dimensional Animation of the Mitral Valve.
J Thorac Cardiovasc Surg. 2004 Mar;127(3):763-9.

27. Sharony R, EA Grossi, PC Saunders, AC Galloway, and SB Colvin.
Repair of Tricuspid Regurgitation: The Posterior Annuloplasty Technique. Operative Techniques in Thoracic and Cardiovascular Surgery. 2003 Nov;8 (4):177-183

28. Saunders PC, Pintucci G, Bizekis CS, Sharony R, Hyman KM, Saponara F, Baumann FG, Grossi EA, Colvin SB, Mignatti P, Galloway AC.
Vein Graft Arterialization Causes Differential Activation of Mitogen-Activated Protein Kinases.
J Thorac Cardiovasc Surg. 2004 May;127(5):1276-84.

29. Lev-Ran O, Pevni D, Nesher N, Sharony R, Paz Y, Kramer A, Mohr R, Uretzky G.
Off-pump coronary artery bypass grafting: single center experience with 1,000 consecutive patients.
Isr Med Assoc J. 2004 Nov;6(11):665-9.

30. Sharony R, Grossi E A, Saunders PC, Schwartz CF, Ribakove GH, Baumann FG, Ursomanno P, Galloway AC, and Colvin SB.
Propensity Case-Matched Analysis Of A Six-Year Experience With Minimally Invasive Isolated Aortic Valve Replacement.
J Heart Valve Dis. 2004 Nov;13(6):887-93.

31. Lev-Ran O, Braunstein R, Hansson N, Pevni D, Sharony R, Bolotin G, Uretzky G.
Off-pump coronary revascularization of the circumflex system: comparison between sequential and nonsequential arterial grafts.
Heart Surg Forum. 2005;8(4):E201-6.

32. Aviram G, Sharony R, Kramer A, Nesher N, Loberman D, Ben-Gal Y, Graif M, Uretzky G, Mohr R.
Modification of Surgical Planning Based on Cardiac Multidetector Computed Tomography in Reoperative Heart Surgery.
Ann Thorac Surg. 2005 Feb;79(2):589-95

33. Sharony R, Frolkis I, Froylich D, Wildhirt SM, Shapira I, Reichart B, Nesher N, Uretzky G.
Pharmacological Preconditioning with Monophosphoryl Lipid A Improves Post Ischemic Diastolic Function and Modifies TNF-alpha Synthesis.
Eur J Cardiothorac Surg. 2005 March; 27(3): 501-507

34. Lev-Ran O, Braunstein R, Sharony R, Kramer A, Paz Y, Mohr R, Uretzky G.
No-touch Aorta Off –Pump Coronary Surgery: The Effect on Stroke.
J Thorac Cardiovasc Surg. 2005 Feb;129(2):307-13

35. Nesher N, Uretzky G, Insler S, Nataf P, Frolkis I, Pineau E, Cantoni E, Bolotin G, Vardi M, Pevni D, Lev-Ran O, Sharony R, Weinbroum AA.
Thermo-wrap technology preserves normothermia better than routine thermal care in patients undergoing off-pump coronary artery bypass and is associated with lower immune response and lesser myocardial damage.
J Thorac Cardiovasc Surg. 2005 Jun;129(6):1371-8.

36. Pevni D, Frolkis I, Shapira I, Schwartz D, Schwartz IF, Chernichovski T, Lev-Ran O, Sharony R, Uretzky G.
Ischaemia or reperfusion: which is a main trigger for changes in nitric oxide mRNA synthases expression? Eur J Clin Invest. 2005 Sep;35(9):546-50.

37. Sharony R, Pintucci G, Saunders PC, Grossi EA, Baumann FG, Galloway AC, Mignatti P.
Matrix Metalloproteinase Expression in Vein Grafts: Role of Inflammatory Mediators and Extracellular Signal-Regulated Kinases-1 and –2.
Am J Physiol Heart Circ Physiol 2006 Apr;290(4):H1651-9. Epub 2005 Nov 11.

38. Pintucci G, Saunders PC, Gulkarov I, Sharony R, Kadian-Dodov DL, Bohmann K, Baumann FG, Galloway AC, Mignatti P.
Anti-proliferative and anti-inflammatory effects of topical MAPK inhibition in arterialized vein grafts.
FASEB J. 2006 Feb;20(2):398-400. Epub 2005 Nov 22.

39. Sharony R, Grossi EA, Saunders PC, Schwartz CF, Ursomanno P, Ribakove GH, Galloway AC, Colvin SB.
Minimally Invasive Re-operative Isolated Valve Surgery: Early and Mid-term Results.
Journal of Cardiac Surgery. J Card Surg. 2006 May-Jun;21(3):240-4.

40. Ben Gal Y, Sharony R, Keren G, Aviram G, Uretzky G.
Surgical Ventricular Restoration- New Horizons in The Treatment of Ischemic Cardiomyopathy.
Harefua, 2006 May;145(5):352-7.

41. Nesher N, Frolkis I, Vardi M, Sheinberg N, Bakir I, Caselman F, Pevni D, Ben-Gal Y, Sharony R, Bolotin G, Loberman D, Uretzky G, Weinbroum AA.
Higher levels of serum cytokines and myocardial tissue markers during on-pump versus off-pump coronary artery bypass surgery.J Card Surg. 2006 Jul-Aug;21(4):395-402.

42. Aviram G, Mohr R, Sharony R, Medalion B, Kramer A, Uretzky G.
Open heart reoperations after coronary artery bypass grafting: the role of preoperative imaging with multidetector computed tomography. Isr Med Assoc J. 2009 Aug;11(8):465-9.

43. Issan Y, Hochhauser E, Kornowski R, Leshem-Lev D, Lev E, Sharoni R, Vanella L, Puri N, Laniado-Schwartzman M, Abraham NG, Porat E.
Endothelial Progenitor Cell Function Inversely Correlates With Long-term Glucose Control in Diabetic Patients: Association With the Attenuation of the Heme Oxygenase-Adiponectin Axis. Can J Cardiol. 2012 Mar 23.

44. Leviner DB, Medalion B, Baruch I, Sagie A, Sharoni E, Fuks A, Aravot D, Sharony R..
Tricuspid Valve Replacement: The Effect of Gender on Operative Results. J Heart Valve Dis. 2014 Mar;23(2):209-15.

46. Codner P, Orvin K, Assali A, Sharony R, Vaknin-Assa H, Shapira Y, Schwartzenberg S, Bental T, Sagie A, Kornowski R.
Long-Term Outcomes for Patients With Severe Symptomatic Aortic Stenosis Treated With Transcatheter Aortic Valve Implantation. Am J Cardiol. 2015 Aug 14. pii: S0002-9149(15)01769-5.

45. Codner P, Assali A, Vaknin-Assa H, Shapira Y, Orvin K, Sharony R, Sagie A, Kornowski R.
Treatment of Aortic, Mitral and Tricuspid Structural Bioprosthetic Valve Deterioration Using the Valve-in-Valve Technique. J Heart Valve Dis. 2015 May;24(3):345-52.

46. Yedidya I, Goldberg E, Sharoni R, Sagie A, Vaturi M.
Infective Endocarditis Caused by Propionibacterium granulosum. Isr Med Assoc J. 2015 Oct;17(10):642-3.

47. Levi A, Landes U, Assali AR, Orvin K, Sharony R, Vaknin-Assa H, Hamdan A, Shapira Y, Schwartzenberg S, Codner P, Shaul AA, Vaturi M, Gutstein A, Sagie A, Kornowski R.
Long-Term Outcomes of 560 Consecutive Patients Treated With Transcatheter Aortic Valve Implantation and Propensity Score-Matched Analysis of Early- Versus New-Generation Valves. Am J Cardiol. 2017 Jun 1;119(11):1821-1831.

48. Orvin K, Barac YD, Kornowski R, Perl L, Wasserstrum Y, Rubchevsky V, Sharony R, Snir E, Aravot D, Lev EI.
Monitoring platelet reactivity during prasugrel or ticagrelor washout before urgent coronary artery bypass grafting. Coron Artery Dis. 2017 Sep;28(6):465-471.

49. Leitman M, Tyomkin V, Raanani E, Sharony R, Tzatskin L, Peleg E, Blatt A, Vered Z.
Assessment and Management of Acute Severe Mitral Regurgitation in the Intensive Care Unit. J Heart Valve Dis. 2017 Mar;26(2):161-168.

50. Zusman O, Kornowski R, Witberg G, Lador A, Orvin K, Levi A, Assali A, Vaknin-Assa H, Sharony R, Shapira Y, Sagie A, Landes U.
Transcatheter Aortic Valve Implantation Futility Risk Model Development and Validation Among Treated Patients With Aortic Stenosis.n. Am
J Cardiol. 2017 Dec 15;120(12):2241-2246.

51. Long-Term Outcomes after Mitral Valve Replacement and Tricuspid Annuloplasty in Rheumatic Patients.
O Itzhaki Ben Zadok, A Sagie, M Vaturi, Y Shapira, S Schwartzenberg, I Kuznitz, T Shochat, T Bental, I Yedidya, D Aravot, R Kornowski, Ram Sharony. Ann Thorac Surg. 2019 Feb;107(2):539-545..